PREVALENCE OF DIABETES MELLITUS IN CHRONIC LIVER DISEASE PATIENTS

Abstract

Background & Summary: The liver plays a key role in carbohydrate metabolism and gluconeogenesis, helping maintain blood glucose levels and energy supply. Hormones such as insulin, glucagon, cortisol, and catecholamines regulate these processes. Due to its central role in glucose homeostasis, liver dysfunction can lead to glucose intolerance and diabetes. A strong association exists between chronic liver disease (CLD) and impaired glucose metabolism, though the exact mechanisms remain unclear. Objective: To determine the frequency of diabetes mellitus in patients with chronic liver disease. Methodology: This descriptive study included 89 CLD patients from a tertiary care hospital in Lahore. Blood samples (5cc) were collected following standard phlebotomy protocols. Samples were analyzed for glucose (in sodium fluoride tubes) and HbA1c (in EDTA tubes). Results: Of the 89 patients, 49 (55.1%) were male and 40 (44.9%) female. Diabetes was present in 61.8% of patients.Conclusion:  The study found a high prevalence (61.8%) of diabetes in CLD patients. Early detection through glucose and HbA1c monitoring can aid in timely glycemic control and prevention.